From Fiumicino airport you can get the air-terminal to Termini station (central station) then you can take bus #38 or #92 and get off after three stops, or take a taxi (5-10 Euro), or take a walk (10 minutes). Coming with the car you will arrive at the "Grande Raccordo Anulare" or "GRA", a sort of ring street sorrounding Rome. Take it and drive to arrive on the north-est side to an exit named "Nomentana", you will have to exit there and take Via Nomentana (street) in the direction of centre. After 12 km you will arrive at "Piazza di Porta Pia", the entrance of centre (you can recognize it because it is sorrounded by ancient walls and you will pass at the right of a big door), enter and continue till the first cross (Via Nomentana has become Via Venti Settembre and the cross is with Via Piave). After the cross, the first building on the right side of the street is the hotel's one.