Highway A1 Firenze-Roma - exit Valdichiana (coming from north) then follow directions towards Perugia; exit expressway in "Perugia San Faustino". - exit Orte (coming from south)then take the Expressway E45 following the indications to Perugia. Exit expressway E45 in "Perugia Piscille Centro" follow historical centre of Perugia